Objectives:

• Describe the function of a middleware used in the clinical chemistry laboratory

• Discuss the difference assayed and unassayed quality control material

• List the limitations of HIL (hemolysis, icterus and lipermia) on automated analyzers

• Summarize the importance of evaluating lot to lot variation of clinical chemistry reagents

• Discuss the cause of Pseudohyponatremia

To-do List

• Watch video lectures

• Read articles:

  • Six keys to successfully evaluating method performance

  • Best practices in establishing quality control parameters

  • Challenging the status quo on quality control

Method Evaluation

Performance Statistics

Quality Control

Allowable Total Error

Calibrators including Traceability and Commutability

Delta Checks

Middleware

Proficiency Testing

Risk Assessment

Analytical Interferences